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TURNING science fiction into science fact, American doctors are preparing to chill volunteers into a state of suspended animation that could keep them asleep for months.
Medical teams in Los Angeles, Boston and Pittsburgh are racing to become the first to test out new theories of “induced hibernation” which could save lives and also help to send man towards the stars.
Hasan Alam, a surgeon at Massachusetts general hospital and consultant to the US army, is poised to start the first human trials before the end of the year.
Last week he said that he wanted to equip ambulances with a clear saline solution called plasma expander that would be injected into seriously injured victims at the scene of a car accident.
The plasma would rapidly send body temperature from 37C to 10C, slowing the metabolism, delaying the onset of shock and limiting damage from wounds.
Alam has experimented on eight-stone Yorkshire pigs, stopping the heart and electrical activity in the brain for up to two hours before slowly replacing the plasma with warm blood and reviving the animals with no apparent long-term effects.
The plasma could also be tested on soldiers: many survive an initial injury only to die waiting for treatment.
Alam, a trauma specialist, is primarily thinking about the time-critical dash to hospital. But researchers at the University of California, Los Angeles (UCLA) and the Safar Center for Resuscitation Research at the University of Pittsburgh are more ambitious. “You start with 20 minutes and then find the limits – days, weeks, months, we do not yet know,” said a UCLA medical school researcher.
Although it is 20 years since Nasa abandoned work on induced hibernation as a way of helping astronauts to survive long space missions, research began again at the European Space Agency in 2004. Funding has flowed in the United States since October, when Mitsutaka Uchikoshi, 35, strayed from a Japanese office barbecue, fell down a snowy mountain and broke his hip.
He lapsed into a frozen coma, which lasted 24 days until his apparently lifeless body was found and revived in a Kobe hospital. He is now known in Japanese newspapers as the “Bear Man”.
“We don’t know how he survived so long, but his body was preserved in ice for nearly a month and now he is back to normal,” a Kobe doctor said. “If we can understand why, we can save many lives in the future.”
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Gene Mosher - the fetus is not continually asleep for the duration of gestation. Anyway, the reason the fetus is able to survive for 9 months inside the mother is because it recieves everything it needs from the mother - the mother's blood via the placenta brings oxygen and nutrients needed for the develoing fetus to grow. it would be impossible to recreate such a prolonged situation in vitro unless scientists could find a way of supplying these 'hibernating people' with all oxygen and nutrition AND a way of excreting carbon dioxide, urea etc. Also, the body is continually using up energy and breaking down bigger molecules into smaller ones (catabolism) whether we are asleep or awake. The difference lies in the balance between the two processes - neither anabolism nor catabolism ever stops completely in health.
Also, a minor point, but the fetus is not in a continual state of growth - it is a dynamic entity which is constantly growing AND shedding old and dead material.
Nina, Bristol,
Let me guess, as seen on TV. A sleep kit, 7 days, three easy payments of 29.95. I will take two please! Oh yeah, let me know when they get to the vacation packages!
Steve, KC, MO
I will do it. You must pay me.
Donna, Chesapeake, Virginia
Asleep and Awake, Sleeping and Waking, are the behavioral manifestations of Anabolism and Catabolism, the balancing phases of metabolism. If the scientists want to make us sleep, i.e., put us into the metabolic phase which 'specializes' in healing, regeneration and growth, then they need to identify the enzymes cells produce which cause us to wake up and either prevent cells from producing them or prevent the enzymes from having the effect that they do, in every animal.
Slowing down metabolism is the wrong approach. It defeats the real goal, which is to simulate what is going on with the human fetus - continuous sleep, continuous growth, continuous generation - without the need for waking - which is only good for things like moving around to find food and procreating.
Scientists: study the metabolic process in which the fetus lives if you want to prolong anabolism and bypass catabolism - 'make us sleep longer'. Sleep is the metabolic imperative, the daily return to anabolism..
Gene Mosher, Eugene, Oregon, USA
Is this another scam, another way of getting research money out of those who want to live forever - like Americans? Look at cancer research - zillions of poundsds sepnd and the only reason why the cancer figures are going down is because people are giup smoking. Common sense is more important than science any day.....
Ron , London , UK